Making Platelets is a Stressful Job: Megakaryocytic Gene Regulation in Response to Shear Stress
Megakaryocytes, the cells responsible for producing platelets, enter into the bloodstream after they have matured from hematopoietic stem cells found within the bone marrow. Shear stress from laminar flow has implications in numerous cell types. It has been previously shown that shear stress from flow, much like that from blood, is vital for megakaryocyte maturation. Our lab investigates how shear stress alters gene expression to encourage megakaryocyte maturation and platelet production, as well as the role p53 plays in this process.